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. 2022 May 26;9:925080. doi: 10.3389/fcvm.2022.925080

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Copyright © 2022 Cui, Lee, Sun, Zhang, Hill, Li and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of adipokines on endothelium-dependent vasorelaxation of SMA. (A) Adenovirus-mediated adiponectin supplementation improved ACh-induced endothelium-dependent vasorelaxation of SMA in Lepr^db mice, without affecting SNP-induced endothelium-independent vasorelaxation (B). Data represent mean ± SEM. n = 5 mice per group with 1–2 rings per mouse. (C,D) Treatment with recombinant resistin did not affect endothelium-dependent or endothelium-independent vasorelaxation of SMA. Data represent mean ± SEM. n = 6 m Lepr^db, 6 Lepr^db, 4 Lepr^db + resistin with 1–2 rings per mouse. *P < 0.05 vs. m Lepr^db control mice, # p < 0.05 vs. Lepr^db diabetic mice.