Figure 2.

Secondary structure of the 25S and 5.8S rRNAs. (A) 25S rRNA with domains 0 to VI indicated in different colours. All known and predicted snoRNA binding sites [114,120,121] are indicated by black/grey (C/D box) or red/pink (H/ACA box) lines, and modification sites are indicated by circles. The binding regions of RNA helicases, determined by CRAC [64,69,232,238,265], are indicated. Additionally, the binding sites of Npa1, an interaction partner of RNA helicase Dbp6 [52], are indicated. (B) Successive folding of the 25S rRNA [54,61]. Already folded rRNA elements are displayed in bright colours (unfolded regions in faint colours).