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. 2022 May 27;13:889596. doi: 10.3389/fimmu.2022.889596

Figure 1.

Figure 1

Representative clinical signs and scores of tree shrew EAU induced by R14 or IRBP1197–1211. Major clinical signs including conjunctival hyperemia, ciliary injections (arrow), whitish hypopyon spots (triangle), corneal ulcers (black star), and corneal edema (white star), were observed in tree shrews immunized with different dosages of BR14 (A–R) or IRBP1197–1211 (a–r). Average clinical scores per eye of EAU are shown from groups immunized with either R14 (S) or IRBP1197–1211 (s) in CFA. A chronic and/or relapsing course of three representative animals is shown, specifically the time courses of clinical disease from tree shrews immunized with 50 µg of BR14 (T), 300 µg of BR14 (U), 800 µg of BR14 (V), 50 µg of IRBP1197–1211 (t), 300 µg of IRBP1197–1211 (u), and 800 µg of IRBP1197–1211 (v). The curves show the inflammation of eyes checked by slit-lamp biomicroscopy according to previously described criteria. Green circle, right eye; black circle, left eye; D, day post-immunization. (2A–2R) indicates fundus pictures of EAU in tree shrews immunized with BR14 or IRBP1197–1211. Retinal vessels with mild cuffing (black arrow), retinal degeneration (white arrow), generalized changes in reflectivity or hyper-reflectivity, pale optic nerve, opacification, and vascular attenuation were observed during fundus examination in the late stage of tree shrew EAU induced with 300 μg of IRBP1197–1211 (2g–2j) and 800 μg of IRBP1197–1211 (2k–2r). D, day post immunization.