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. 2022 May 27;13:889596. doi: 10.3389/fimmu.2022.889596

Figure 4.

Figure 4

The expressions of P2RY12 and Aβ of human uveitis and tree shrew EAU. P2RY12 (A–Y) was expressed on the cornea, but not on the retina, on day 18 postimmunization with 50 µg of BR14 (A, B) and day 235 postimmunization with 800 µg of IRBP (U–W). On day 26 postimmunization with 50 µg of BR14, P2RY12 was weakly expressed on the cornea and retina (C, D). However, strong expression of P2RY12 was observed on the cornea and various layers of the retina on day 87 postimmunization with 50 µg of BR14 and days 26, 45, 87, and 235 postimmunization with 50 µg of BR14 (C, D), 300 µg of BR14 (F–J), 50 µg of IRBP (K–O), 300 µg of IRBP (P–T), 800 µg of IRBP (U, V), and human uveitis (W–Y). The positive expression of Aβ (a-j) was not observed in the retinal lesions on day 18 postimmunization with 50 µg of BR14 (a), but weak expression was observed in the ciliary processes, retinal layer, and retinal lesions on day 45 postimmunization with 50 µg of BR14 animals (b, c), on days 26 (d, e) and 45 (f) post-immunization with 300 µg of BR14, on days 9 (g) and 235 (h, i) postimmunization with 800 µg of IRBP, and in the human retina (j).