TABLE 4.
Overview about anti-HIV-1 activity of Viola tricolor peptide subfractions.
| Fr. # | Without washing | With washing | ||||||
|---|---|---|---|---|---|---|---|---|
| IC50 (µg/ml or nM) | CC50 (µg/ml) | SI (CT) | IC50 (µg/ml or nM) | CC50 (µg/ml) | SI (CT) | |||
| VT | CT | VT | CT | |||||
| 4.1 | 2.6 ± 0.4 | 11.2 ± 9.0 | 60.4 ± 1.9 | 8.1 ± 5.4 | 5.2 ± 2.0 | 5.3 ± 2.3 | >100 | >21.7 ± 10.8 |
| 4.2 | 0.8 ± 0.2 | 1.8 ± 0.3 | 5.5 ± 0.3 | 3.1 ± 0.3 | 1.4 ± 0.4 | 1.7 ± 0.8 | 7.5 ± 0.4 | 4.9 ± 2.0 |
| 4.3 | 1.1 ± 0.3 | 2.9 ± 0.7 | 15.4 ± 1.3 | 5.5 ± 1.2 | 0.8 ± 0.0 | 2.4 ± 1.2 | 25.9 ± 2.1 | 12.5 ± 5.3 |
| 4.4 | 0.7 ± 0.1 | 3.0 ± 0.5 | 12.9 ± 1.0 | 4.4 ± 0.4 | 0.6 ± 0.2 | 2.9 ± 0.9 | 20.6 ± 0.9 | 7.5 ± 1.8 |
| mara. | 3.8 ± 1.0 | 4.3 ± 1.8 | - | - | 3.7 ± 1.4 | 3.3 ± 1.2 | - | - |
CC50 and IC50 were determined by nonlinear regression from concentration-response curves (Figure 4) and are given in µg/ml units for fractions and nM units for maraviroc. Values represent means ± SD of three independent experiments in triplicates. SI was calculated by dividing CC50 by IC50. Since 100 μg/ml was the highest concentrations used, no higher half-maximal concentrations could be calculated. CT, cell treatment; VT, virus treatment; mara, maraviroc.