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. 2022 May 30;12:817192. doi: 10.3389/fonc.2022.817192

Figure 1.

Figure 1

Identification of circDNMT1 characteristics in GC. (A) The schematic illustration of circDNMT1 origination and the result of Sanger sequencing. (B) The gel electrophoresis to examine amplified product of qRT-PCR using convergent and divergent primers. (C) FISH to display the distributions of cricDNMT1 in HGC-27 and AGS cells. Scale bar: 10 μm. (D) The qRT-PCR analysis to show circDNMT1 expression in 50 pairs of GC and adjacent normal tissues. (E) The Kaplan-Meier plot to show survival time of 50 GC patients who were divided into high-circDNMT1 and low-circDNMT1 groups. (F) The qRT-PCR analysis to show circDNMT1 expression in HGC-27, AGS, MKN-45, MKN-28, MGC-803, BGC-823 and GES-1 cell lines. Data were presented as means ± SD. *P < 0.05, **P < 0.01; ***P < 0.001, ****P < 0.0001.