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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Nature. 2022 May 25;606(7912):146–152. doi: 10.1038/s41586-022-04783-1

Extended Data Fig. 6|. CCR5/CCL5 signaling regulates memory linking in an appetitive place preference task.

Extended Data Fig. 6|

a-f, Place preference-based behavior model to test the linking of contextual memories.

a, Schematics of place preference-based linking behavior.

b, Representative trajectory plot (in the 3rd minute) of mice in the pre-exposed context and a novel context with a 5h and 7d interval.

c, d, Mice showed a significant preference for pre-exposed context during the 3rd minute in the 5h group compared to the 7d group (5h, n=13, 7d n=12 mice; *P < 0.05, one sample paired t-test compared to 50%)

e, Representative trajectory plot (in the 3rd minute) of mice in the pre-exposed context and a novel context with Vehicle or CCL5 infusion.

f, CCL5 infusion in dCA1 impaired contextual memory linking with a 5h interval (Veh n=7, CCL5 n=8; **P < 0.01, one sample paired t-test compared to 50%).

g, Ccl5 knockout extended the temporal window of contextual memory linking (WT n=11, Ccl5−/− n=16; *P < 0.05, **P < 0.01, two-way repeated measures ANOVA).

All results shown as mean ± s.e.m.