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. 2022 May 27;13:849101. doi: 10.3389/fphar.2022.849101

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Copyright © 2022 Li, Liu, Song, Chen, Zhu, Yu, Huang, Zhang, Xue, Hua, Lu, Lu and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Histological findings of synovial tissues from healthy mice and CIA mice on day 28 after different treatments. H&E (synovial inflammation, original magnifications × 100, and immunohistochemical staining for IL-1β, IL-6, and TNF-α, original magnifications × 20) (B) Semiquantitative analysis of histopathological evaluation (synovial inflammation and immunohistochemical staining for IL-1β, IL-6, and TNF-α). Asterisks (*) represent significance compared with the untreated mice at *p < 0.05.