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. 2022 Jun 1;11:e77030. doi: 10.7554/eLife.77030

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© 2022, Edmond et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Author response image 1. — (a) Currents from oocytes expressing KCNQ2-N190C channels in response to 20-mV voltage steps from – 140-mV to + 40-mV (left) before and (right) after application of MTSET in the open state. (middle) currents in response to a + 20-mV voltage steps during MTSET application on N190C channels in the open state for the indicated voltage protocol. MTSET is applied at + 20-mV for 5-s in between 25-s washouts for 8-15 cycles and the change in current is measured at + 20-mV. (b) Normalized steady-state conductance/voltage relationships, G(V), (lines from a Boltzmann fit) of N190C channels (black) before and (gray ‘closed state’ and yellow ‘open state’) after MTSET application. Summary of (c) relative change in current amplitude and (d) voltage dependence shift of MTSET-mediated modification of N190C channels in the open state. (e) Summary table of the G(V) values from each experiment. Values from the original submission are shown in red. (e’) Statistical analysis from red values. Significance was determined using the paired Student’s t-test and significance level was set at P < 0.05. Asterisks denote significance: p < 0.01**.