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. 2022 May 31;15:881954. doi: 10.3389/fnmol.2022.881954

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Copyright © 2022 Xu, Wei, Zhang, Chen, Dong, Shi, Wu, Zhang, Li, Zhang, Li and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dysregulated genes in MCA specimens from MMD and AS-ICASO controls. (A) A volcano plot to visualize the DEGs between MMD and AS-ICASO controls. Magenta dots represent significantly (p < 0.05 and fold change >2) upregulated genes (n = 449), and indigo dots represent significantly downregulated genes (n = 107). Gary dots represent the genes that are not differentially expressed. (B) A principal component analysis (PCA) biplot for PC1 and PC2, performed using all of the normalized values obtained from the sequencing data, shows two separate clusters for MMD and AS-ICASO controls. Dark red dots represent patients with MMD, yellow dots represent participants with AS-ICASO. (C) Heatmap shows a distinct expression pattern of DEGs between MMD and AS-ICASO controls. The color key at the right indicates a relative gene expression. Yellow and green colors represent higher and lower gene expression levels, respectively.