Skip to main content
. Author manuscript; available in PMC: 2022 Nov 26.
Published in final edited form as: Nat Microbiol. 2022 May 26;7(6):918–927. doi: 10.1038/s41564-022-01128-6

Fig. 6: A model for recoding in the phage life cycle.

Fig. 6:

Infection of a standard code host begins with the production of proteins from standard code compatible genes. In some phage, this is a route to integrase production and establishment of lysogeny. In other phage, this early phase involves the production of molecules involved in switching from standard to alternative code such as suppressor tRNAs (Sup tRNA), amino acyl tRNA synthetases (aaRS) and release factors (RF1/2). As infection proceeds, recoded gene products initially suppressed by in-frame recoded stop codons code can be produced. This allows for expression of phage structural proteins and ultimately triggers lysis.