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. 2022 May 31;13:879686. doi: 10.3389/fimmu.2022.879686

Figure 2.

Figure 2

Differential degranulation by neutrophil subsets from COVID-19 patients. (A) Basal and stimulated (TNFα 2 ng/ml + fMLF 300 nM) expression of markers for secretory vesicles (CD35), gelatinase granules (CD11b), specific granules (CD66b), and azurophilic granules (CD63) on COVID NDN (n=11-15), COVID LDN (n=11-15), and HD NDN (n=8-9). Results are expressed as mean ± SEM of mean fluorescent intensity (MFI). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. (B) Comparison of basal expression of CD35, CD11b, CD66b, and CD63 on COVID NDN, CD16Hi LDN, and CD16Int LDN (n=7). Results are expressed as mean ± SEM of MFI. *p < 0.05, **p < 0.01, ***p < 0.001. (C) Plasma levels of MMP9, lactoferrin, and human neutrophil elastase in plasma from HD (n=10) and COVID-19 (n=10-25). Results expressed as mean + SEM in ng/ml. *p < 0.05, **p < 0.01, ***p < 0.001.