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. 2022 Jun 15;162(5):1006–1016. doi: 10.1016/j.chest.2022.06.007

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© 2022 The Author(s)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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In situ IL-8 mRNA and NETs in pulmonary thrombi from patients with fatal COVID-19. A, Photomicrograph depicting hematoxylin and eosin stain of lung tissue showing an organizing thrombus in a medium vessel. B, C, Fluorescence images of the pulmonary thrombus showing a high density of NETs. NETs are visualized as white structures by the marker combinations CD15 (blue channel), MPO (red channel), and H3Cit (green channel). D, E, High IL-8 mRNA signal (yellow channel) is found in the organizing thrombus. Fluorescence images for each of the individual markers are shown in e-Fig 11. Scale bars represent 200 μm. H3Cit = anti-histone H3; MPO = myeloperoxidase; mRNA = messenger RNA; NET = neutrophil extracellular trap.