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. 2022 Jun 15;162(5):1006–1016. doi: 10.1016/j.chest.2022.06.007

Figure 5.

Figure 5

CD8+ T-cell infiltration and NETs in the lung tissue of patients with fatal COVID-19. A, Representative fluorescence image of lung tissue with a high density of NETs. NET-rich areas tend to have low CD8+ T-cell infiltrations. B, Representative fluorescence image of lung tissue with a very low density of NETs. Low neutrophil infiltration (magenta, CD15 [blue channel], MPO [red channel]), and high CD8+ T-cell infiltrations are seen. C, Fluorescence image showing prominent NET formation surrounding peribronchiolar areas with discrete CD8+ T-cell infiltration. D, Scatterplot showing correlation between NETs and CD8+ T cells in whole-tissue sections. Fluorescence images for each of the individual markers are shown in e-Fig 12. Scale bars represent 500 μm (A), 100 μm (B), and 50μm (C). H3Cit = anti-histone H3; MPO = myeloperoxidase; NET = neutrophil extracellular trap.