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. Author manuscript; available in PMC: 2023 Apr 27.
Published in final edited form as: J Am Chem Soc. 2022 Apr 15;144(16):7208–7214. doi: 10.1021/jacs.1c13455

Figure 1.

Figure 1.

Cryo-EM structure of the α2β2 complex (left) and ordered PCET pathway (right), where ET and PT denote electron transfer and proton transfer, respectively. The participation of W48 is uncertain and therefore is shown in square brackets. Y731 has been shown computationally and experimentally to sample both flipped-out (green) and stacked (black) conformations. The PCET reaction between Y730 and C439 is indicated with a purple square bracket.