Table 1.
Cytotoxic effects of the DNMTi MC3343 in EWS cell lines.
| Cell line | MC3343 IC50 μM |
|---|---|
| TC-71 | 2.48 ± 0.66 |
| LAP-35 | 5.89 ± 0.06 |
| 6647 | 3.99 ± 0.82 |
| SK-N-MC | 2.96 ± 0.17 |
| SK-ES-1 | 3.96 ± 0.56 |
| IOR/CAR | 3.83 ± 0.41 |
| A673 | 2.20 ± 0.23 |
| RD-ES-1 | 5.39 ± 0.09 |
| PDX-EW#2-C | 4.58 ± 0.84 |
| PDX-EW#4-C | 2.28 ± 0.18 |
| PDX-EW#5-C | 3.05 ± 0.64 |
IC50 values (drug concentration inducing 50% of growth inhibition) were calculated after 72h exposition to the drug in 11 EWS cell lines. The mean ± SE of three independent experiments are reported.