Extended Data Fig. 6. Correlations with north and east birth coordinates.

Associations between SNPs and north and east birth coordinates that persist after principal component adjustment were assessed by performing a genome-wide association study of north and east birth coordinates in a sample of unrelated individuals from the ‘White British’ subsample of the UK Biobank (Methods). We estimated genome-wide correlations between SNP associations with north and east birth coordinate and a) direct effects, b) average non-transmitted coefficients (NTCs), and c) population effects on 9 phenotypes (Methods). Point estimates are plotted as points, with error bars giving 95% confidence intervals. See Supplementary Table 6 for numerical results. Abbreviations: AAFB, age at first birth; BMI, body mass index; FEV1, forced expiratory volume in one second; HDL, high-density lipoprotein cholesterol.