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. 2022 May 27;13:872286. doi: 10.3389/fimmu.2022.872286

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Copyright © 2022 Guo, Mao, Tian, Liao, Su, Ye, Shi, Liu, Ling and Hao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of STAT3 phosphorylation diminishes IL-17 production in response to C. neoformans. Peripheral blood mononuclear cells were pretreated for 30 min with STAT3 phosphorylation inhibitor stattic (2.5μM) and were subjected to stimulation for 3 days with C. neoformans. Changes of the phosphorylated STAT3 (A) and IL-17-producing cells (B, C) were analyzed by flow cytometry assay, and the supernatant IL-17 level (mean ± SE) was evaluated by ELISA (D). Representative data of three individual experiments are shown. ***0.0001<p<0.01, ^****p < 0.0001; ns, no significance.