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. 2022 Jun 14;13:3422. doi: 10.1038/s41467-022-30480-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Indel profile divergence between controls and selected clones. Blue bars highlight clone/gRNA combinations that were significantly affected (FDR-corrected p < 0.01 from a chi-squared distribution, see Methods). B Change in frequency of individual indels relative to controls. 'D' = deletion, 'I' = insertion, 'M' = microhomology (see Methods). X axis indicates the frequency in control clones. Y axis indicates relative change in indel frequency in a given clone relative to control clones. Complete loss of the indel is at −100%, while 100% indicates doubled frequency. The axis is truncated there for display clarity. Only indels present at 0.3% frequency or higher in control clones are shown. Dashed lines indicate absolute change of 0.1% and 1% respectively, color gradations highlight this change. Biological replicates (N = 2) were averaged for clarity. All columns relate to the same gRNAs as in panel (A).