Suggested future research directions for ICANS related studies:
Utilize consensus grading ICANS scales across studies
Develop and validate risk prediction models for the identification of those most likely to develop high-grade ICANS related complications
Conduct longitudinal studies to assess the long-term outcomes following CAR-T cell therapy with a focus on late-term neurotoxic complications
Evaluate the effects of CAR-T cell therapy in real-world populations and more vulnerable populations such as older adults
Develop interventions to support, manage or prevent the onset of ICANS