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. 2021 May 26;27(4):1261–1279. doi: 10.1007/s10741-021-10119-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Calculation of segmental myocardial work by pressure strain-analysis. Myocardial work by pressure strain analysis is calculated as a function of time throughout the cardiac cycle. The calculational steps include (1) the differentiation of the segmental strain (%) in order to obtain the strain rate (%/s) which was then (2) multiplied with the left ventricular pressure (mmHg). This results in a measure of instantaneous LV power (mmHg %/s). To finally obtain segmental myocardial work over time (mmHg %), (3) the instantaneous LV power has to be integrated over time. MVC mitral valve closure, AVO atrial valve opening, AVC atrial valve closure, MVO mitral valve opening