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. 2021 May 26;27(4):1261–1279. doi: 10.1007/s10741-021-10119-4

Table 1.

Validation of non-invasive pressure-strain loops as a surrogate of myocardial work

Author Title Year Journal Number of patients Results
Russel et al. A novel clinical method for quantification of regional left ventricular pressure–strain loop area: a non-invasive index of myocardial work 2012 European Heart Journal 18 Non-invasive assessed regional LV pressure–strain loop area corresponds well with invasive measurements and reflects myocardial metabolism
Russel et al. Assessment of wasted myocardial work: a novel method to quantify energy loss due to uncoordinated left ventricular contractions 2013 American Journal of Physiology-Heart and Circulatory Physiology 48 Energy loss caused by uncoordinated contractions can be measured as the LV wasted work ratio non-invasively
Hubert et al. Estimation of myocardial work from pressure–strain loops analysis: an experimental evaluation 2018 European Heart Journal—Cardiovascular Imaging 9 The non-invasive assessment of LV myocardial work by pressure strain analysis correlates well with invasive measurements
Cauwenberghs et al. Area of the pressure-strain loop during ejection as non-invasive index of left ventricular performance: a population study 2019 Cardiovascular Ultrasound 356 Integration of the LV pressure–strain loop during ejection might be a useful tool to non-invasively evaluate sex-specific and interdependent effects of preload and afterload on LV myocardial performance
Manganaro et al. Echocardiographic reference ranges for normal non-invasive myocardial work indices: results from the EACVI NORRE study 2019 European Heart Journal Cardiovascular Imaging 226 The NORRE study provides reference ranges for non-invasive MW indices
Manganaro et al. Correlation between non-invasive myocardial work indices and main parameters of systolic and diastolic function: results from the EACVI NORRE study 2019 European Heart Journal Cardiovascular Imaging 226 Non-invasively assessed MW indices correlate well with common 2DE measures of myocardial systolic function and strain
Galli et al. Echocardiographic reference ranges for myocardial work in healthy subjects: A preliminary study 2019 Echocardiography 115 Referral ranges of GCW, GWI, GWW, and GWE are not dependent on age

MW myocardial work, 2DE two-dimensional echocardiography, GCW global myocardial constructive work, GWI global myocardial work index, GWW global myocardial wasted work, GWE global myocardial work efficiency