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. 2021 May 26;27(4):1261–1279. doi: 10.1007/s10741-021-10119-4

Table 2.

Non-invasive myocardial work and cardiac resynchronization therapy (CRT)

Author Title Year Journal Number of patients Results
Vecera, J. et al. Wasted septal work in left ventricular dyssynchrony: a novel principle to predict response to cardiac resynchronization therapy 2016 European Heart Journal Cardiovascular Imaging 21 Wasted work in the septum together with LV wall motion score can give a better prediction of response to CRT
Galli et al. Role of myocardial constructive work in the identification of responders to CRT 2018 European Heart Journal Cardiovascular Imaging 97 Patients with higher GCW show a positive response to CRT
Galli et al. Value of myocardial work estimation in the prediction of response to cardiac resynchronization therapy 2018 Journal of the American Society of Echocardiography 97 WW and CW are useful indexes to better understand CRT response and mechanisms of dyssynchrony
Van der Bijl et al.

Prognostic implications of global, left ventricular myocardial work efficiency before cardiac resynchronization

therapy

2019 European Heart Journal Cardiovascular Imaging 153 Lower baseline GLVMWE predicts improved long-term outcome
Galli et al. Myocardial constructive work and cardiac mortality in resynchronization therapy candidates 2019 American Heart Journal 166 CW predicts outcome in CRT candidates
Zhu et al. The value of left ventricular strain–volume loops in predicting response to cardiac resynchronization therapy 2019 Cardiovascular Ultrasound 60 Measurement of baseline septal WW can improve patient selection for CRT
Kostyukevich et al. Regional left ventricular myocardial work indices and response to cardiac resynchronization therapy 2020 JACC: Cardiovascular Imaging 168 CRT responders show larger septal WW and lateral CW at baseline and demonstrate a significant improvement in septal CW and WW as well as a decrease and an increase in lateral CW and WW respectively
Duchenne et al. Acute redistribution of regional left ventricular work by cardiac resynchronization therapy determines long-term remodeling 2020 European Heart Journal 130 The acute redistribution of regional myocardial work between the septal and lateral wall is an important predictor of CRT response

CRT cardiac resynchronization therapy, GCW global myocardial constructive work, CW constructive work, WW wasted work, GLVMWE global left ventricular myocardial work efficiency