Table 2.

Lactylation in Diseases

Disease	Enzyme regulation	Histone modification	Cell proliferation	Protein targets	Gene targets	References
SCC	SIRT6		TPCs	GSH		[41]
Ocular melanoma		Lysine		YTHDF2	m6A	[42]
Lung fibrosis		Lysine	Macrophage			[43]

It has been demonstrated that glycolysis can proliferate TPCs in SCC. However, the mechanism of lactylation in SCC is unclear