Table 1.
Clinical studies of regional delivery of CAR T Cells
| Cancer | Target (Costimulation) | Delivery | Sample Size | NCT # | Phase/Site First Author, Publication, Year Study Features/Notable Findings |
|---|---|---|---|---|---|
| Breast | c-Met (4–1BB) | Intratumoral | 6 | NCT01837602 | Phase 0/University of Pennsylvania |
| CNS (glioblastoma, pediatric diffuse pontine glioma, diffuse midline glioma) | B7-H3 | Intracranial Intraventricular |
— | NCT04185038 | Phase I/Seattle Children’s Hospital |
| EGFR806 | Intracranial Intraventricular |
— | NCT03638167 | Phase I/Seattle Children’s Hospital | |
| EGFRvIII | Intracerebral | — | NCT03283631 | Phase I/National Cancer Institute, Duke University | |
| HER2 | Intracranial Intraventricular |
3 | NCT03500991 | Phase I/Seattle Children’s Hospital | |
| HER2 | Intracranial | — | NCT02442297 | Phase I/Baylor College | |
| HER2 | Intraventricular | — | NCT03696030 | Phase I/National Cancer Institute | |
| IL13Rα2 | Intracranial | 3 | NCT00730613 | Phase I/City of Hope | |
| IL13Rα2 (4–1BB) | Intracavitary Intratumoral Intraventricular |
1 | NCT02208362 | Phase I/City of Hope | |
| IL13Rα2 (CD28) | Intratumoral | 6 | NCT01082926 | Phase I/City of Hope | |
| Cavitary (ovarian, fallopian tube, primary peritoneal, peritoneal mesothelioma, peritoneal metastases) | CEA | Intraperitoneal | — | NCT03682744 | Phase I/Rutgers, Roger Williams Medical Center |
| Folate receptor–alpha | Intraperitoneal | — | NCT03585764 | Phase I/University of Pennsylvania | |
| Mesothelin | Intraperitoneal | 11 | NCT03608618 | Phase I/National Cancer Institute | |
| Muc16 (CD28/IL-12 secreting) | Intraperitoneal Intravenous |
18 | NCT02498912 | Phase I/Memorial Sloan Kettering | |
| Head and neck Squamous | ErbB | Intratumoral | NCT01818323 | Phase I/King’s College London Guy’s and St Thomas |
|
| Liver metastases (from colorectal, pancreatic) | CEA (CD28) | Intrahepatic | 6 | NCT01373047 | Phase I/Roger Williams Medical Center |
| CEA (CD28) | Intrahepatic | 8 | NCT02416466 | Phase I/Roger Williams Medical Center | |
| CEA (CD28) | Intrahepatic | 1 | NCT02850536 | Phase I/Roger Williams Medical Center | |
| Tag-72 | Intrahepatic Intravenous |
6 | — | Phase I/University of California, San Francisco, Stanford Mary Crowley | |
| Mesothelin-expressing cancers (lung adenocarcinoma, ovarian, fallopian tube, pleural and peritoneum mesothelioma) |
Mesothelin | Intrapleural Intravenous |
— | NCT03054298 | Phase I/University of Pennsylvania |
| Thoracic (lung, pleural disease, mesothelioma) | FAP | Intrapleural | 3 | NCT01722149 | Phase I/University of Zurich |
| Mesothelin (CD28) | Intrapleural | 41 | NCT02414269 | Phase I/II/Memorial Sloan Kettering | |
| Mesothelin (1XX/PD1DNR) | Intrapleural | — | NCT04577326 | Phase I/Memorial Sloan Kettering Cancer |
We searched PubMed and the National Clinical Trials website for clinical trials related to the following search terms: “CAR T cells regional delivery,” “CAR T cells locoregional delivery,” “intracerebral,” “intrahepatic,” “intrapleural,” “intratumoral,” and “intraventricular.”