FIGURE 4.

Kv3.2 conservation of the S6 transmembrane domain in the Shaker ortholog and Kv1.1 paralog. (a) BLAST of the Drosophila melanogaster Shaker ortholog to the Kv3.2 protein reveals high conservation of the S6 transmembrane domain and complete conservation at the 473 Valine amino acid position. (b) BLAST of the human Kv1.1 paralog to the Kv3.2 protein reveals high conservation of the S6 transmembrane domain and complete conservation at the 473 Valine amino acid position. These two proteins were compared since the Valine to Alanine change at the same protein location as in Kv3.2 has already revealed functional consequences of the change in both the Kv1.1 and Shaker proteins