Table 1.
Demonstration of reproducible results
| Published Results | |||
|---|---|---|---|
| Overall survival | Events/Evaluable | Hazard Ratio (95% confidence interval) | p-value |
| Age | |||
| ≤12 years | 22/491 | 1.00 | |
| 13 – 49 years | 54/419 | 3.15 (1.86 – 5.34) | <0.0001 |
| Regimen intensity | |||
| Non-myeloablative | 7/181 | 1.00 | |
| Myeloablative | 41/478 | 4.62 (1.87 – 11.44) | 0.0009 |
| Reduced intensity | 28/251 | 3.79 (1.46 – 9.84) | 0.006 |
| Donor type | |||
| HLA-matched sibling | 21/558 | 1.00 | |
| Haploidentical relative | 13/137 | 2.94 (1.26 – 6.87) | 0.013 |
| HLA-matched unrelated | 26/111 | 5.12 (2.79 – 9.40) | <0.0001 |
| HLA-mismatched unrelated | 16/104 | 4.88 (2.22 – 10.75) | <0.0001 |
| Results from Public Database with Additional Follow up for Published Cohort | |||
| Overall survival | Events/Evaluable | Hazard Ratio (95% confidence interval) | p-value |
| Age | |||
| ≤12 years | 23/491 | 1.00 | |
| 13 – 49 years | 59/419 | 3.50 (2.16 – 5.79) | <0.0001 |
| Regimen intensity | |||
| Non-myeloablative | 9/181 | 1.00 | |
| Myeloablative | 44/478 | 3.59 (1.57 – 8.21) | 0.002 |
| Reduced intensity | 29/251 | 3.08 (1.29 – 7.39) | 0.012 |
| Donor type | |||
| HLA-matched sibling | 25/558 | 1.00 | |
| Haploidentical relative | 13/137 | 2.70 (1.29 – 5.67) | 0.009 |
| HLA-matched unrelated | 27/111 | 4.36 (2.47 – 7.70) | <0.0001 |
| HLA-mismatched unrelated | 17/104 | 3.55 (1.90 – 6.65) | <0.0001 |