Table 1.
Cohort summary of final PICU and CTICU cohorts. IQR: interquartile range. AVDSf: alveolar dead-space fraction.
| PICU | CTICU | |
|---|---|---|
| Subjects, n | 902 | 1292 |
| No. of observations | 6681 | 9610 |
| No. of observations per subject, median (IQR) | 3 (1–9) | 4 (2–9) |
| Time between BG (h) | 5.1 (3.2–7.7) | 4.3 (2.5–6.5) |
| Age, mo, median (IQR) | 60.6 (16.4–151.1) | 1.0 (0.0–7.2) |
| Weight, kg, median (IQR) | 18.0 (9.6–39.4) | 3.6 (2.9–6.4) |
| Female (%) | 42.8% | 42.2% |
| Arterial blood gas, median (IQR) | ||
| pH | 7.35 (7.30–7.43) | 7.39 (7.34–7.46) |
| PaO2 (mmHg) | 89 (69–116) | 75 (45–121) |
| PaCO2 (mmHg) | 45 (38–54) | 44 (39–49) |
| Noninvasive support | ||
| SpO2 (%) | 98 (96–100) | 97 (85–100) |
| PetCO2 (mmHg) | 40 (34–47) | 38 (33–43) |
| Ventilator settings | ||
| Peak inspiratory pressure (cmH2O) | 24 (19–30) | 20 (17–24) |
| PEEP (cmH2O) | 8.0 (5.3–10.0) | 5.5 (5.0–7.0) |
| Mean airway pressure (cmH2O) | 13.5 (10.0–17.2) | 9.7 (8.0–11.5) |
| FiO2 (%) | 40 (33–60) | 40 (35–60) |
| Tidal volume (exp) (mL/kg) | 7.2 (5.5–8.9) | 7.5 (5.7–8.8) |
| Minute ventilation (L/min/kg) | 153.8 (110.2–211.9) | 203.7 (165.7–244.4) |
| Lung disease severity | ||
| OSI | 8.7 (5.3–13.2) | 4.6 (3.0–6.9) |
| OI | 5.7 (2.9–12.2) | 4.8 (3.1–9.4) |
| SpO2/FiO2 | 238 (163–286) | 228 (161–278) |
| PaO2/FiO2 | 211 (128–323) | 186 (115–282) |
| AVDSf | 0.11 (0.01–0.21) | 0.13 (0.04–0.22) |