Table 1.
Baseline characteristics of IIM patients.
| All IIM patients (n = 49) |
IIM patients without Cardiac involvement (n = 12) | IIM patients with Cardiac involvement (n = 37) |
p value | |
|---|---|---|---|---|
| Diagnostic subgroups | – | |||
| PM, n (%) | 30 (61) | 7 (58) | 23 (62) | |
| DM, n (%) | 4 (8) | 0 (0) | 4 (11) | |
| IMNM, n (%) | 14 (29) | 4 (33) | 10 (27) | |
| IBM | 1 (2) | 1 (9) | 0 (0) | |
| Age, years | 42 ± 16 | 37 ± 17 | 43 ± 16 | 0.712 |
| Female, n (%) | 37 (76) | 9 (75) | 28 (76) | 0.962 |
| BMI, kg/m2 | 22 ± 5 | 22 ± 3 | 22 ± 5 | 0.650 |
| Heart rate, bpm | 85 ± 17 | 82 ± 6 | 86 ± 19 | 0.843 |
| Duration of IIM, median (IQR), years | 0.4 (0.3–1.0) | 0.8 (0.3–4.0) | 0.4 (0.2–1.0) | 0.065 |
| hs cTnI, pg/ml | 4.3 (1.9–21.7) | 2.2 (1.9–4.3) | 5.9 (1.9–25.9) | 0.011 |
| NT–proBNP, pg/ml | 81.0 (36.0–208.8) | 24.0 (23.0–39.0) | 79.0 (34.8–261.0) | 0.226 |
| CK, U/L | 1238.0 (231.0–3731.0) | 636.0 (301.0–2160.0) | 1238.0 (231.0–3332.0) | 0.926 |
| CK–MB, ng/ml | 23.3 (3.0–112.4) | 21.7 (2.0–58.6) | 23.3 (3.4–146.7) | 0.390 |
| Myoglobin, ng/ml | 315.1 (95.0–1200.0) | 161.7 (94.5–301.8) | 289.7 (91.8–1200.0) | 0.372 |
| Lactate dehydrogenase, U/L | 424.0 (247.0–834.0) | 323.0 (218.0–391.0) | 487.5 (326.0–863.8) | 0.070 |
| hs CRP, mg/l | 2.2 (0.5–3.9) | 1.3 (0.6–2.8) | 2.2 (0.4–3.1) | 0.701 |
| MDAAT cardiac activity VAS | 1.3 ± 0.9 | – | 1.7 ± 0.6 | – |
| Clinical cardiovascular symptoms | 2 (4) | – | 2 (5) | |
| Abnormal hs cTnI (M, > 34.2 pg/ml, F, > 15.6 pg/ml), n (%) | 14 (29) | 0 (0) | 14 (38) | – |
| Abnormal electrocardiography, n (%) | 24 (49) | 0 (0) | 24 (65) | – |
| Abnormal standard echocardiography, n (%) | 9 (18) | 0 (0) | 9 (24) | – |
| Abnormal standard CMR, n (%) | 30 (61) | 0 (0) | 30 (81) | – |
Data are expressed as N (%), mean ± standard deviation, or median (interquartile range).
IIM, idiopathic inflammatory myopathy; PM, polymyositis; DM, dermatomyositis; IMNM, immune-mediated necrotizing myopathy; BMI, body mass index; SD, standard deviation; IQR, interquartile; hs cTnI, high-sensitive cardiac troponin I; NT-proBNP, N-terminal pro brain natriuretic peptide; CK, creatine kinase; hs CRP, high-sensitive C reactive protein; NSAID, nonsteroidal anti-inflammatory drug; MDAAT, the Myositis Disease Activity Assessment Tool; VAS, visual analogue; CMR, cardiac magnetic resonance.
Bold value denote statistical significance (p < 0.05).