Table 1.

Study design scheme by dosing sequence.

Dosing sequence	Expected number of evaluable subjects (N)	Period 1 (visit 1; day 1)	Period 2 (visit 2; day 8)	Period 3 (visit 3; day 15)
A	4	Low-dose sublingual	High-dose sublingual	IV
B	4	High-dose sublingual	IV	Low-dose sublingual
C	4	IV	Low-dose sublingual	High-dose sublingual

IV, intravenous atropine sulfate 1.0 mg (0.4 mg/mL) administered via IV route

Low-dose sublingual = 0.5 mg (50 µL) of atropine sulfate 1% ophthalmic solution, administered via sublingual route

High-dose sublingual = 1.0 mg (100 µL) of atropine sulfate 1% ophthalmic solution, administered via sublingual route