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. 2022 Jun 15;19:149. doi: 10.1186/s12974-022-02514-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — SARS-CoV-2 infection of hBMECs induced a severe inflammatory response. A Heat maps depicting virally regulated cytokines and chemokines upon SARS-CoV-2 infection in hBMECs. Colored bar represents expressive abundance of log2 transformed values. B Significance analysis and difference multiples of cytokines and chemokines in hBMECs upon SARS-CoV-2 infection. C RT-qPCR analysis of cytokines and chemokines transcription in hBMECs upon SARS-CoV-2 infection. RPL13A was used as the internal reference. Data were presented as the mean ± SD from three independent experiments. *p < 0.05, ***p < 0.001. D Heat maps depicting virally regulated cytokine receptors upon SARS-CoV-2 infection in hBMECs. Colored bar represents expressive abundance of log2-transformed values. E Significance analysis and difference multiples of cytokine receptors in hBMECs upon SARS-CoV-2 infection. F RT-qPCR analysis of cytokine receptors transcription in hBMECs upon SARS-CoV-2 infection. RPL13A was used as the internal reference. Data were presented as the mean ± SD from three independent experiments. *p < 0.05, ***p < 0.001