Table 1.
List of all FDA approved oncology drugs with available in vitro resistance data.
| Agent | Mechanism of action | Target/Classification | Category |
|---|---|---|---|
| 5-fluorouracil | antimetabolite | DNA | chemotherapy |
| abemaciclib | CDK inhibitor | CDK inhibitor | targeted |
| abiraterone | antiandrogen | hormonal | hormonal |
| afatinib | EGFR inhibitor | signal transduction inhibitor | targeted |
| alectinib | ALK inhibitor | signal transduction inhibitor | targeted |
| alpelisib | PI3K inhibitor | signal transduction inhibitor | targeted |
| axitinib | anti-angiogenesis | signal transduction inhibitor | targeted |
| azacitidine | antimetabolite, hypomethylating agent | DNA | chemotherapy |
| belinostat | HDAC inhibitor | HDAC inhibitor | chemotherapy |
| bendamustine | alkylating agent | DNA | chemotherapy |
| bexarotene | retinoid receptor agonist | differentiating agent | miscellaneous |
| bicalutamide | antiandrogen | hormonal | hormonal |
| binimetinib | MEK inhibitor | signal transduction inhibitor | targeted |
| bleomycin | antitumor antibiotic | DNA | chemotherapy |
| bortezomib | proteasome inhibitor | proteasome inhibitor | chemotherapy |
| bosutinib | BCR-ABL inhibitor | signal transduction inhibitor | targeted |
| brigatinib | ALK inhibitor | signal transduction inhibitor | targeted |
| busulfan | alkylating agent | DNA | chemotherapy |
| cabazitaxel | antimicrotubular agent | DNA | chemotherapy |
| cabozantinib | multiple receptor tyrosine kinase inhibitor | signal transduction inhibitor | targeted |
| carfilzomib | proteasome inhibitor | proteasome inhibitor | chemotherapy |
| carmustine | alkylating agent | DNA | chemotherapy |
| cetuximab | EGFR inhibitor | signal transduction inhibitor | targeted |
| chlorambucil | alkylating agent | DNA | chemotherapy |
| cisplatin | platinum analog | DNA | chemotherapy |
| cladribine | antimetabolite | DNA | chemotherapy |
| clofarabine | antimetabolite | DNA | chemotherapy |
| cobimetinib | MEK inhibitor | signal transduction inhibitor | targeted |
| crizotinib | multiple receptor tyrosine kinase inhibitor | signal transduction inhibitor | targeted |
| cyclophosphamide | alkylating agent | DNA | chemotherapy |
| cytarabine | antimetabolite | DNA | chemotherapy |
| dabrafenib | BRAF inhibitor | signal transduction inhibitor | targeted |
| dacarbazine | alkylating agent | DNA | chemotherapy |
| dacomitinib | EGFR inhibitor | signal transduction inhibitor | targeted |
| dactinomycin | antitumor antibiotic | DNA | chemotherapy |
| dasatinib | BCR-ABL inhibitor | signal transduction inhibitor | targeted |
| daunorubicin | antitumor antibiotic | DNA | chemotherapy |
| decitabine | antimetabolite | DNA | chemotherapy |
| docetaxel | antimicrotubular agent | DNA | chemotherapy |
| doxorubicin | antitumor antibiotic | DNA | chemotherapy |
| epirubicin | antitumor antibiotic | DNA | chemotherapy |
| erdafitinib | FGFR inhibitor | signal transduction inhibitor | targeted |
| erlotinib | EGFR inhibitor | signal transduction inhibitor | targeted |
| estramustine | antimicrotubular agent | DNA | chemotherapy |
| etoposide | topoisomerase inhibitor | DNA | chemotherapy |
| etoposide-phosphate | topoisomerase inhibitor | DNA | chemotherapy |
| everolimus | mTOR inhibitor | signal transduction inhibitor | targeted |
| fedratinib | JAK inhibitor | signal transduction inhibitor | chemotherapy |
| floxuridine | antimetabolite | DNA | chemotherapy |
| fludarabine | antimetabolite | DNA | chemotherapy |
| fulvestrant | antiestrogen | hormonal | hormonal |
| gefitinib | EGFR inhibitor | signal transduction inhibitor | targeted |
| gemcitabine | antimetabolite | DNA | chemotherapy |
| hydroxyurea | antimetabolite | DNA | chemotherapy |
| ibrutinib | BTK inhibitor | signal transduction inhibitor | targeted |
| idarubicin | antitumor antibiotic | DNA | chemotherapy |
| idelalisib | PI3K inhibitor | signal transduction inhibitor | targeted |
| ifosfamide | alkylating agent | DNA | chemotherapy |
| imatinib | BCR-ABL inhibitor | signal transduction inhibitor | targeted |
| Irinotecan | topoisomerase inhibitor | DNA | chemotherapy |
| ixabepilone | antimicrotubular agent | DNA | chemotherapy |
| ixazomib | proteasome inhibitor | proteasome inhibitor | chemotherapy |
| lapatinib | ERBB inhibitor | signal transduction inhibitor | targeted |
| lenalidomide | immunomodulatory | miscellaneous | miscellaneous |
| lenvatinib | multiple receptor tyrosine kinase inhibitor | signal transduction inhibitor | targeted |
| mechlorethamine | alkylating agent | DNA | chemotherapy |
| melphalan | alkylating agent | DNA | chemotherapy |
| mercaptopurine | antimetabolite | DNA | chemotherapy |
| methotrexate | antimetabolite | DNA | chemotherapy |
| midostaurin | FLT3 inhibitor | signal transduction inhibitor | targeted |
| mitomycin-c | antitumor antibiotic | DNA | chemotherapy |
| mitoxantrone | antitumor antibiotic | DNA | chemotherapy |
| nelarabine | antimetabolite | DNA | chemotherapy |
| neratinib | ERBB inhibitor | signal transduction inhibitor | targeted |
| nilotinib | BCR-ABL inhibitor | signal transduction inhibitor | targeted |
| niraparib | PARP inhibitor | signal transduction inhibitor | targeted |
| olaparib | PARP inhibitor | signal transduction inhibitor | targeted |
| mepesuccinate | BCR-ABL inhibitor | signal transduction inhibitor | targeted |
| osimertinib | EGFR inhibitor | signal transduction inhibitor | targeted |
| oxaliplatin | platinum analog | DNA | chemotherapy |
| paclitaxel | antimicrotubular agent | DNA | chemotherapy |
| palbociclib | CDK inhibitor | CDK inhibitor | targeted |
| panobinostat | HDAC inhibitor | HDAC inhibitor | chemotherapy |
| pazopanib | multiple receptor tyrosine kinase inhibitor | signal transduction inhibitor | targeted |
| pemetrexed | antimetabolite | DNA | chemotherapy |
| ponatinib | BCR-ABL inhibitor | signal transduction inhibitor | targeted |
| pralatrexate | antimetabolite | DNA | chemotherapy |
| procarbazine | alkylating agent | DNA | chemotherapy |
| regorafenib | multiple receptor tyrosine kinase inhibitor | signal transduction inhibitor | targeted |
| ribociclib | CDK inhibitor | CDK inhibitor | targeted |
| romidepsin | HDAC inhibitor | HDAC inhibitor | chemotherapy |
| rucaparib | PARP inhibitor | signal transduction inhibitor | targeted |
| selinexor | XPO inhibitor | nuclear export inhibitor | targeted |
| selumetinib | MEK inhibitor | signal transduction inhibitor | targeted |
| sirolimus | mTOR inhibitor | signal transduction inhibitor | targeted |
| sonidegib | hedgehog inhibitor | signal transduction inhibitor | targeted |
| sorafenib | multiple receptor tyrosine kinase inhibitor | signal transduction inhibitor | targeted |
| sunitinib | multiple receptor tyrosine kinase inhibitor | signal transduction inhibitor | targeted |
| talazoparib | PARP inhibitor | signal transduction inhibitor | targeted |
| tamoxifen | antiestrogen | hormonal | hormonal |
| tazemetostat | histone lysine methyltransferase inhibitor | methyltransferase inhibitor | targeted |
| temozolomide | alkylating agent | DNA | chemotherapy |
| temsirolimus | mTOR inhibitor | signal transduction inhibitor | targeted |
| teniposide | topoisomerase inhibitor | DNA | chemotherapy |
| thioguanine | antimetabolite | DNA | chemotherapy |
| tipiracil | antimetabolite | DNA | chemotherapy |
| tirbanibulin | microtubule inhibitor | DNA | chemotherapy |
| tivozanib | anti angiogenesis | signal transduction inhibitor | targeted |
| topotecan | topoisomerase inhibitor | DNA | chemotherapy |
| toremifene | antiestrogen | hormonal | hormonal |
| trametinib | MEK inhibitor | signal transduction inhibitor | targeted |
| tucatinib | ERBB inhibitor | signal transduction inhibitor | targeted |
| valrubicin | topoisomerase inhibitor | DNA | chemotherapy |
| vandetanib | multiple receptor tyrosine kinase inhibitor | signal transduction inhibitor | targeted |
| venetoclax | BCL2 inhibitor | signal transduction inhibitor | targeted |
| vinblastine | microtubule inhibitor | DNA | chemotherapy |
| vincristine | microtubule inhibitor | DNA | chemotherapy |
| vinorelbine | microtubule inhibitor | DNA | chemotherapy |
| vismodegib | hedgehog inhibitor | signal transduction inhibitor | targeted |
| vorinostat | HDAC inhibitor | HDAC inhibitor | chemotherapy |