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. 2022 Jun 1;9:918789. doi: 10.3389/fmolb.2022.918789

FIGURE 5.

FIGURE 5

MMPs’ sensible peptides in imaging techniques. (A) MMP cleavable peptide included in an activable cell-penetrating peptide (ACPP) was integrated into the N-BP5-Gd-ACPP nanoprobe favoring its cell uptake. (B) Fluorescence image of hepatocellular carcinoma HepG2 cells incubated with N-BP5-Gd-ACPP. Incubations with N-BP5-Gd were not visible under the fluorescence microscope (not shown in the figure) (C) Fluorescence images show the differences between HepG2 tumor-bearing animals injected with N-BP5-Gd-ACPP or N-BP5-Gd. (D) MR images demonstrate the rapid distribution of the N-BP5-Gd-ACPP nanoprobe in the tumors compared to animals injected with N-BP5-Gd. Adapted with permission from Xia, B., Yan, X., Fang, W.W., Chen, S., Jiang, Z., Wang, J., et al. (2020). Activatable Cell-Penetrating Peptide Conjugated Polymeric Nanoparticles with Gd-Chelation and Aggregation-Induced Emission for Bimodal MR and Fluorescence Imaging of Tumors. ACS Appl. Bio. Mater 3, 1394–1405. doi: 10.1021/acsabm.9b01049. Copyright 2020 American Chemical Society. Abbreviations: MMP, matrix metalloproteinase.