TABLE 1.
TIMPs’ characteristics.
| Property | TIMP-1 | TIMP-2 | TIMP-3 | TIMP-4 |
|---|---|---|---|---|
| kDa | 28 | 21 | 24/27 | 22 |
| Amino acid residues | 184 | 194 | 188 | 194 |
| N-glycosylation sites | Asn-30, Asn-79 | 0 | Asn-130 | 0 |
| MMPs weak inhibition | MMP-14, MMP-15, MMP-16, MMP-19, MMP-24 | None | None | None |
| Pro-MMP interaction | Pro-MMP-9 | Pro-MMP-2 | Pro-MMP-2/-9 | Pro-MMP-2 |
| ADAMS inhibition | ADAM-10 | ADAM-12 | ADAM-10, ADAM-12, ADAM-17, ADAM-19, ADAM-28, ADAM-33 | ADAM-17, ADAM-28, ADAM-33 |
| ADAMTS inhibition | None | None | ADAMTS-1, ADAMTS-2, ADAMTS-4, ADAMTS-5 | None |
ADAMS, a desintegrin and metalloproteinases; ADAMTS, a desintegrin and metalloproteinases with thrombospondin motifs; MMP, matrix metalloproteinase; TIMP, tissue inhibitor of metalloproteinases.