TABLE 2.
EFV effects on the retinal transcriptome of 5XFAD mice in the 2nd treatment.
| DEGs/Total genes | Fold enrichment | GO biological processes and DEGs involved |
|---|---|---|
| Regulation of cell adhesion (GO: 0030155) | ||
| 24/773 | 3.2 | Agr2, Bst1, Cd47, Dock5, Dscam, Dusp1, Dusp26, Efnb2, Emilin1, Enpp2, Glmn, Gpnmb, H2-Ob, Hmgb1, Il4i1, Mbp, Mex3b, Mip, Nr4a3, Pkd1, Rag1, Sema3e, Slc7a1, Thbs1 |
| Regulation of proteolysis (GO: 0030162) | ||
| 20/740 | 2.8 | Alad, Clu, Eno1, Glmn, Hmgb1, Itih3, Mbp, Nkd2, Pcsk1n, Pi15, Pkd1, Prelid1, Prkaca, Rag1, Rnf144a, Styx, Tfap4, Thbs1, Trib2, Ubb |
| Blood vessel development (GO: 0001568) including regulation of angiogenesis GO: 0045765) | ||
| 13/538 | 2.5 | Adgrf4, Col1a2, Col5a1, Col8a2, Edn2, Efnb2, Glmn, Jmjd6, Nat1, Pkd1, Sema3e, Stra6, Thbs1 |
| Positive regulation of apoptotic process (GO: 0043065) | ||
| 14/597 | 2.4 | Bmf, Clu, Dusp1, Egln1, Hmgb1, Nr4a3, Prelid1, Prkdc, Rpl26, Sik1, Tfap4, Thbs1, Ubb, Zmat3 |
| Monocarboxylic acid metabolic process (GO: 0032787) | ||
| 13/510 | 2.6 | Aldoa, Ech1, Edn2, Eno1, Fads,2 Il4i1, Lpin2, Nr4a3, Pfkfb2, Pfkl, Pkm, Rdh16f2, Tnxb |
| Visual system development (GO: 0150063) | ||
| 12/393 | 3.2 | Ache, Bfsp2, Col5a1, Col8a2, Crybb1, Crybb3, Dscam, Hmgb1, Jmjd6, Mip, Rpe65, Stra6 |
| Translation (GO:0006412) | ||
| 11/323 | 3.5 | Mrps10, Rbm4, Rpl21, Rpl23a, Rpl26, Rpl28, Rpl35, Rpl41, Rplp0, Rps15, Rps28 |
| Regulation of mitotic cell cycle (GO: 0007346) | ||
| 11/456 | 2.5 | Bub1b, Cdc26, Gpnmb, Hmgb1, Kcnh5, Nup62, Pkd1, Prkdc, Rpl26, Sik1, Tfap4, |
| Negative regulation of immune system process (GO: 0002683) | ||
| 11/460 | 2.5 | Cd47, Dusp1, Emilin1, Glmn, Gpnmb, H2-Ob, Hmgb1, Il4i1, Mmp28, Prkdc, Thbs1 |
| ADP metabolic process (GO:0046031) including ATP generation from ADP (GO: 0006757) | ||
| 6/55 | 11.3 | Aldoa, Ampd3, Eno1, Pfkfb2, Pfkl, Pkm |
| Glycolytic process (GO: 0009135) | ||
| 6/58 | 10.7 | Aldoa, Ampd3, Eno1, Pfkfb2, Pfkl, Pkm |
| Pyruvate metabolic process (GO: 0006090) | ||
| 6/70 | 8.9 | Aldoa, Eno1, Nr4a3, Pfkfb2, Pfkl, Pkm |
| Regulation of interleukin-10 production (GO: 0032653) | ||
| 5/62 | 8.3 | Cd47, Hmgb1, Mbp, Trib2, Tusc2 |
| Visual perception (GO:0007601) including sensory perception of light stimulus (GO: 0050953) | ||
| 10/161 | 6.4 | Bfsp2, Crybb1, Crybb3, Guca1b, Lrat, Mip, Myo7a, Pde6g, Rpe65, Wfs1 |
Statistical overrepresentation of the DEGs in the GO biological processes as identified by the PANTHER software (Mi et al., 2019).