TABLE 2.
Univariate and multivariate Cox proportional analyses to identify the OS predictors for patients with NSCLC
| Terms | Univariate Cox analysis | Multivariate Cox analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| NAC cohort | ||||||
| Tumor metabolic classifier | 5.591 | 2.678‐11.670 | <0.001 | 3.823 | 1.716‐8.514 | 0.001 |
| Stroma metabolic classifier | 4.626 | 2.446‐8.749 | <0.001 | 2.180 | 1.004‐4.737 | 0.049 |
| MPR | 0.465 | 0.260‐0.830 | 0.010 | 0.913 | 0.445‐1.874 | 0.804 |
| TNM staging | 1.304 | 1.082‐1.571 | 0.005 | 1.223 | 0.977‐1.550 | 0.078 |
| Chemo‐naïve cohort | ||||||
| Tumor metabolic classifier | 2.836 | 1.603‐5.016 | <0.001 | 1.767 | 0.971‐3.217 | 0.063 |
| Stroma metabolic classifier | 6.118 | 3.219‐11.630 | <0.001 | 4.953 | 2.517‐9.747 | <0.001 |
| TNM staging | 2.570 | 1.200‐5.502 | 0.015 | 1.417 | 0.653‐3.075 | 0.379 |
Abbreviations: OS, overall survival; NSCLC, non‐small cell lung cancer; HR, hazards ratio; CI, confidence interval; NAC, neoadjuvant chemotherapy; MPR, major pathologic response; TNM, tumor‐node‐metastasis; Chemo, chemotherapy