Summary of findings 4. Post‐haemodialysis dietary supplement versus normal diet for people with CKD‐MBD.
| Post‐haemodialysis dietary supplement versus normal diet for people with CKD‐MBD | ||||||
| Patient or population: people with CKD‐MBD undergoing haemodialysis Settings: HD unit Intervention: post‐haemodialysis dietary supplement Comparison: normal diet | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| Normal diet | Post‐haemodialysis dietary supplement | |||||
| Serum phosphorus Follow‐up: mean 1 month | Mean serum phosphorus (control) 2.1 mmol/L | Mean serum phosphorus (intervention) 0.12 mmol/L higher (0.24 lower to 0.49 higher) | 54 (2) | ⊕⊝⊝⊝ Very low1,2 | ||
| Serum phosphorus ‐ home‐prepared dietary supplement versus normal diet Follow‐up: mean 1 month | Mean serum phosphorus (control) 2.1 mmol/L | Mean serum phosphorus (intervention) 0.06 mmol/L higher (0.45 lower to 0.57 higher) | 30 (1) | ⊕⊝⊝⊝ very low1,3 | ||
| Serum phosphorus ‐ commercial dietary supplement versus normal diet Follow‐up: mean 1 month | Mean serum phosphorus (control) 2.1 mmol/L | Mean serum phosphorus (intervention) 0.19 mmol/L higher (0.34 lower to 0.72 higher) | 24 (1) | ⊕⊝⊝⊝ very low1,3 | ||
| Mortality | Not reported | Not reported | Not estimable | ‐ | Not estimable | |
| Cardiovascular events | Not reported | Not reported | Not estimable | ‐ | Not estimable | |
| Fracture | Not reported | Not reported | Not estimable | ‐ | Not estimable | |
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval | ||||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
1 Studies reported using randomised controlled methods, but did not report details of random sequence generation, allocation concealment, or blinding 2 Only published, small studies were included. Some negative results were reported. 3 Only one published study was included.