Table 1.
Clinical and pathological characteristics of patients.
| Characteristics | All patients | GradeⅡ/Ⅲ | Grade Ⅳ | P Value |
|---|---|---|---|---|
| Count, n (%) | 187 (100) | 99 (52.9) | 88 (47.1) | |
| Sex, n (%) | 0.944 | |||
| Female | 76 (40.6) | 40 (40.4) | 36 (40.9) | |
| Male | 111 (59.4) | 59 (59.6) | 52 (59.1) | |
| Age (y) (Mean ± SD) | 50.3 ± 12.9 | 45.0 ± 12.0 | 56.3 ± 11.2 | <0.001 |
| Location | 0.855 | |||
| Frontal | 55 (29.4) | 32 (32.3) | 23 (26.1) | |
| Temporal | 41 (21.9) | 20 (20.2) | 21 (23.9) | |
| Parietal | 17 (9.1) | 8 (8.1) | 9 (10.2) | |
| Multiple | 36 (19.3) | 18 (18.2) | 18 (20.5) | |
| Others | 38 (20.3) | 21 (21.2) | 17 (19.3) | |
| KPS (Mean ± SD) | 78.1 ± 14.9 | 85.3 ± 9.0 | 70.2 ± 16.1 | <0.001 |
| Radio- and/or chemotherapy, n (%) | <0.001 | |||
| Yes | 129 (69.0) | 79 (79.8) | 50 (56.8) | |
| No | 51 (27.3) | 14 (14.1) | 37 (42.0) | |
| Missing | 7 (3.7) | 6 (6.1) | 1 (1.1) | |
| Resection, n (%) | <0.001 | |||
| GTR | 81 (43.3) | 54 (54.5) | 27 (30.7) | |
| Non-GTR | 102 (54.5) | 41 (41.4) | 61 (69.3) | |
| Missing | 4 (2.1) | 4 (4.0) | 0 (0) | |
| IDH1R132H, n (%) | <0.001 | |||
| Yes | 59 (31.6) | 55 (55.6) | 4 (4.5) | |
| No | 119 (63.6) | 36 (36.4) | 83 (94.3) | |
| Not done | 9 (4.8) | 8 (8.1) | 1 (1.1) | |
| MGMT promoter methylation, n (%) | 0.001 | |||
| Yes | 91 (48.7) | 58 (58.6) | 33 (37.5) | |
| No | 79 (42.2) | 30 (30.3) | 49 (55.7) | |
| Not done | 17 (9.1) | 11 (11.1) | 6 (6.8) | |
| WBC (109/L) (Mean ± SD) | 6.8 ± 2.5 | 6.5 ± 2.5 | 7.1 ± 2.4 | 0.016 |
| Neutrophil (109/L) (Mean ± SD) | 4.5 ± 2.3 | 4.0 ± 2.3 | 5.0 ± 2.3 | 0.001 |
| Lymphocyte (109/L) (Mean ± SD) | 1.7 ± 0.9 | 1.9 ± 1.2 | 1.5 ± 0.5 | 0.023 |
| Platelet (109/L) (Mean ± SD) | 190.4 ± 55.4 | 181.8 ± 50.7 | 200.1 ± 59.1 | 0.082 |
| Monocyte (109/L) (Mean ± SD) | 0.5 ± 0.2 | 0.5 ± 0.2 | 0.5 ± 0.2 | 0.535 |
| Albumin (g/L) (Mean ± SD) | 39.9 ± 3.5 | 40.1 ± 3.7 | 39.7 ± 3.3 | 0.417 |
| NLR (Mean ± SD) | 3.2 ± 2.4 | 2.6 ± 2.1 | 3.8 ± 2.6 | <0.001 |
| PLR (Mean ± SD) | 130.0 ± 65.5 | 115.9 ± 57.8 | 145.8 ± 70.3 | 0.001 |
| LMR (Mean ± SD) | 3.8 ± 1.6 | 4.0 ± 1.5 | 3.5 ± 1.7 | 0.015 |
| AGR (Mean ± SD) | 1.6 ± 0.3 | 1.6 ± 0.3 | 1.5 ± 0.2 | 0.003 |
| OS (months) (Mean ± SD) | 18.7 ± 12.4 | 25.1 ± 12.4 | 12.0 ± 8.2 | <0.001 |
KPS, Karnofsky performance status; GTR, gross total resection; IDH, isocitrate dehydrogenase; MGMT, O6-methylguanine-DNA methyltransferase; NLR, neutrophil to lymphocyte ratio; PLR, platelet to lymphocyte ratio; LMR, lymphocyte to monocyte ratio; AGR,albumin to globulin ratio; OS, overall survival.