Table 2.
Univariate and multivariate analyses of OS in GBM cohorts.
| Variables | Univariate Analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Sex (female/male) | 1.174 (0.729-1.891) | 0.509 | / | / |
| Age (<60/≥60) | 0.684 (0.428-1.092) | 0.111 | / | / |
| Location | 1.097 (0.935-1.287) | 0.258 | / | / |
| KPS (<60/≥60) | 13.422(6.618-27.223) | <0.001 | 6.117(2.795-13.388) | <0.001 |
| Radio- and/or chemotherapy (no/yes) | 9.098 (4.874-16.982) | <0.001 | 3.539 (1.683-7.443) | 0.001 |
| Resection (GTR/non-GTR) | 4.096 (2.303-7.286) | <0.001 | 2.573 (1.321-5.012) | 0.005 |
| IDH1R132H (yes/no) | 1.671 (0.525-5.322) | 0.385 | 1.079 (0.320-3.641) | 0.902 |
| MGMT promoter methylation(yes/no) | 1.655 (0.991-2.763) | 0.054 | 1.631 (0.928-2.865) | 0.089 |
| Neutrophil (≥4.7/<4.7) (109/L) | 1.564 (0.982-2.491) | 0.059 | 1.001 (0.551-1.818) | 0.998 |
| Lymphocyte (≥2.3/<2.3) (109/L) | 0.539 (0.195-1.486) | 0.232 | / | / |
| Platelet (≥208/<208) (109/L) | 1.284 (0.790-2.086) | 0.313 | / | / |
| Albumin (<35.7/≥35.7) (g/L) | 2.545 (1.278-5.070) | 0.008 | 1.585 (0.672-3.738) | 0.292 |
| NLR (≥2.0/<2.0) | 2.217 (1.247-3.942) | 0.007 | 2.519 (1.220-5.204) | 0.013 |
| PLR (≥213.0/<213.0) | 1.381 (0.756-2.524) | 0.294 | / | / |
| LMR (<2.3/≥2.3) | 2.062 (1.221-3.484) | 0.007 | 2.268 (1.172-4.386) | 0.015 |
| AGR (<1.7/≥1.7) | 2.632 (1.377-5.025) | 0.003 | 2.924 (1.389-6.135) | 0.005 |
KPS, Karnofsky performance status; GTR, gross total resection; IDH, isocitrate dehydrogenase; MGMT, O6-methylguanine-DNA methyltransferase; NLR, neutrophil to lymphocyte ratio; PLR, platelet to lymphocyte ratio; LMR, lymphocyte to monocyte ratio; AGR, albumin to globulin ratio; HR, hazard ratio; CI, confidence interval.