Table 4.

Total protein, albumin, urea, uric acid, creatinine, bilirubin, triglyceride, glycemia, alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), and cholesterol serum concentration in dogs treated with dietary supplementation of PTHL and untreated dogs (CON) for 90 days.

Parameter	Group	Time (days)				SEMa	p -value			Reference valuec
		0	30	60	90		Group	Time	G × Tb
Total protein (g/dL)	CON	6.67	6.55	7.00	6.72	0.325	0.049	0.904	0.591	5.4–7.1
	PTHL	6.38	6.10	6.12	6.16
Albumin (g/dL)	CON	2.98	2.95	3.05	2.95	0.105	0.671	0.748	0.985	2.6–3.3
	PTHL	3.02	2.94	2.98	2.90
Urea (mmol/L)	CON	59.26	58.95	53.70	60.10	9.890	0.459	0.290	0.919	21–60
	PTHL	52.26	51.02	55.02	57.44
Uric acid (mg/dL)	CON	0.81	0.92	1.20	1.15	0.190	0.036	0.202	0.534	0.0–2.0
	PTHL	0.62	0.58	0.64	0.86
Creatinine (mg/dL)	CON	1.42	1.50	1.42	1.42	0.100	0.047	0.473	0.529	0.5–1.5
	PTHL	1.32	1.28	1.34	1.32
Bilirubine (mg/dL)	CON	0.26	0.40	0.47	0.42	0.135	0.016	0.135	0.426	0.1–0.5
	PTHL	0.22	0.18	0.24	0.38
Triglyceride (mg/dL)	CON	36.98	32.40	32.57	31.30	9.105	0.337	0.179	0.542	30.1–38.1
	PTHL	38.57	38.62	35.60	37.26
Glycemia (mg/dL)	CON	86.96	61.20	81.60	71.70	6.100	0.008	0.174	0.163	65–118
	PTHL	89.43	86.74	87.04	88.70
ALTd (IU/L)	CON	31.82	38.50	53.30	36.75	5.750	0.335	0.154	0.230	21–102
	PTHL	34.65	43.20	34.96	34.64
ASTe (IU/L)	CON	24.78	27.47	27.15	28.30	2.215	0.442	0.511	0.241	0.0–66.0
	PTHL	21.74	23.86	22.00	23.76
ALPf (IU/L)	CON	22.50	19.05	23.40	16.52	5.115	0.178	0.932	0.649	20–156
	PTHL	23.39	23.78	26.04	28.86
Cholesterol (mg/dL)	CON	172.46	182.90	206.67	201.40	18.650	0.089	0.374	0.747	135–270
	PTHL	163.06	153.42	168.78	177.32

^aStandard error of the means.

^bGroup × Time.

^cKaneko et al. (45).

^dAlanine aminotransferase.

^eAspartate aminotransferase.

^fAlkaline phosphatase.