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. 2022 Jun 1;13:778755. doi: 10.3389/fphar.2022.778755

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Copyright © 2022 Zhou, Wang, Sun, Liu, Rong, Luo, Yue, Xiao, Yang, Lu, Luo, Zhou, Zhu, Yang, Xiong, Yu, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Topical application of aloperine ameliorates psoriasis induced by IMQ. (A) Representative presentation of the back skin at day 7 of the IMQ treatment. (B) The severity was graded by a modified PASI. (C) Histological analysis of the mouse back skin by H&E staining. (D) Histological analysis of IHC staining for Ki-67. Corresponding quantification analyses of epidermal thickness and positive proliferation cells were carried out as described. The values are presented as the mean ± SEM (n = 10 mice per group). ∗p < 0.05; ∗∗p < 0.01; and ∗∗∗p < 0.001.