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. 2022 Jun 1;13:778755. doi: 10.3389/fphar.2022.778755

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Copyright © 2022 Zhou, Wang, Sun, Liu, Rong, Luo, Yue, Xiao, Yang, Lu, Luo, Zhou, Zhu, Yang, Xiong, Yu, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Aloperine facilitates the conversion of Th17 to Treg. (A) Flow cytometry analysis of the conversion of Th17 into Treg. (B) Western-blot analysis was conducted to assess the influence of aloperine in the phosphorylation of STAT5 and STAT3. (C) Real-time PCR analysis of IL-17A, RORγt, and Foxp3 in Th17 cells following 48 h of Treg polarization conditions with or without aloperine. The results were from three independent experiments. The values are presented as the mean ± SEM. ∗p < 0.05; ∗∗p < 0.01; and ∗∗∗p < 0.001.