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. 2022 Jun 1;13:902305. doi: 10.3389/fphar.2022.902305

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Copyright © 2022 Fu, Dou, Zou, Lu, Wang, Liu, Liu, Wang, Jin and Kong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Amlodipine inhibits A549 cell proliferation by blocking the cell cycle G0/G1 phase. (A) Incubation of A549 with various concentrations (1, 2, 5, 10, 15, and 20 μM) of amlodipine (Aml) for 48 h. The effects of amlodipine on A549 cell proliferation were determined by MTT assay. (B) A549 cells were harvested 48 h after treatment with indicated concentrations of amlodipine, and apoptotic cells were measured by flow cytometry analysis. (C) Cells were pre-incubated with different concentrations of amlodipine for 48 h, and the induction of cell cycle arrest was detected by flow cytometry analysis. (D) The percentage of total cells at G0/G1, S, and G2/M phases. (E) The expressions levels of cell cycle-related proteins were determined by Western blotting after treatment with amlodipine. Data are presented as mean ± SD of three independent experiments. *p < 0.05, **p < 0.01 and ***p < 0.001.