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. 2022 Jun 1;13:902305. doi: 10.3389/fphar.2022.902305

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Copyright © 2022 Fu, Dou, Zou, Lu, Wang, Liu, Liu, Wang, Jin and Kong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Amlodipine combined with gefitinib induces cycle arrest in A549 cells. (A) Amlodipine combined with gefitinib increased the proportion of cells in the G0/G1 phase. (B) The percentage of total cells at G0/G1, S, and G2/M phases. (C) The levels of p-Rb and p27 were measured by Western blotting after treatment with amlodipine, gefitinib, or a combination of the two agents. (D) Phosphorylation and total levels of Akt, mTOR, and EGFR were analyzed by Western blotting after treatment with amlodipine, gefitinib, or a combination of the two agents. Data are presented as mean ± SD of three independent experiments. *p < 0.05 and ***p < 0.001.