Fig. 2.

Tau Immunostaining and Novel Parcellation at Eight Anterior-Posterior Levels: Eight medial temporal lobe levels from anterior to posterior of a representative case (case 6, Braak and Braak II), immunostained with phosphorylated tau (CP13) antibody. All tissue sections illustrated in coronal plane. The following levels list a nearby landmark that best identifies each coronal level. Level One = anterior to the amygdala (a), Level Two = at anterior amygdala (b), Level Three = at posterior amygdala (c), Level Four = genu, anterior hippocampal head (d), Level Five = pes region (gyrus uncinatus) in the hippocampal head (e), Level Six = hippocampal head and dentate gyrus (f), Level Seven = posterior-most hippocampal head ends (gyrus intralimbicus) (g) (see also Fig. 5g and Supplementary Figure 1g), Level Eight = at anterior hippocampal body (h). EO, entorhinal olfactory; ER, entorhinal rostral; EMI, entorhinal medial intermediate; EI, entorhinal intermediate; ELr, entorhinal lateral rostral; ELc, entorhinal lateral caudal; ECs, entorhinal caudal; ECL, entorhinal caudal limiting; ECs_Lat, ECs Lateral; ECs_Med, ECs Medial; EI_Lat, EI Lateral; EI_Med, EI Medial. Magnification bar = 5 mm.