Fig. 5.

Manually Labeled Ex Vivo MRI: Semi-quantitative tau burden scores manually labeled on eight anterior-posterior levels (panels a-h) of a single case (case 6, Braak and Braak II). Labeled colors reflect corresponding semi-quantitative tau burden scores from Fig. 4. Blue labeling (score 0) means no CP13 tau pathology, no NFTs, no NTs. Green labeling (score 1) means very low tau/NFT burden and essentially isolated tangles in this region. Note that the green labels were restricted to medial and anterior subregions. Orange (score 2) conveys a moderate tau burden both in number of NFTs and NFT packing density. Rust (score 3) translated to a high tau burden and showed more densely packed and strongly stained NFTs and pretangles with substantial NTs. Burgundy (score 4) showed the greatest density for phosphorylated tau at CP13, with a large number of closely packed, immunostained NFTs and NTs blanketing most of the area. Black arrows point to the gyrus uncinatus (e) and the gyrus intralimbicus (g).