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. 2022 May 3;87(1):433–441. doi: 10.3233/JAD-215542

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© 2022 – The authors. Published by IOS Press

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) License.

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Fig. 5 — Kaplan-Meier survival curve. For the analysis has been considered the age of onset for AD patients and the age of conversion for the MCI-AD. The number of subjects at risk respectively at: the 25% percentile, median, and 75% percentile of Median time for each group are reported. The test showed that patients with higher serum levels of BACE1 (of the median (16.67 kU/L): BACE > 50) anticipate the pathology of 8 years (77 > 69, p = 0.008, Breslow test, BACE < = 50 group: Median time = 77; 25% Percentile = 73.56; 75% Percentile = 80.44; BACE > 50 group: Median time = 69; 25% Percentile = 65.28; 75% Percentile = 72.71).