Table 1.
Demographic, clinical, and biological presentation of all subjects
| CTRL (n = 30) | AD (n = 31) | MCI-AD (n = 28) | p | |
| Sex (% F) | 70% | 70% | 71% | 0.963a |
| Age, y (Mean±SD) | 71.23±4.81 | 69.16±10.65 | 69.89±9.07 | 0.867b |
| Disease onset, y (Median; 25%; 75%) | – | 68.00; 60.00; 75.00 | 69.50; 65.00; 73.25 | 0.682c |
| Education, y (Mean±SD) | 10.50±4.04 | 7.06±3.23 | 7.33±3.63 | < 0.001b |
| MMSE (Mean±SD) | 27.97±0.32 | 18.37±5.58 | 25.15±2.16 | < 0.001b |
| Aβ1 - 42 CSF (pg/ml) (Mean±SD) | – | 353.60±149.60 | 374.00±122.80 | 0.572d |
| P-Tau 181 CSF (pg/ml) (Median; 25%; 75%) | – | 78.04; 67.65; 114.60 | 87.41; 56.47; 110.40 | 0.855c |
| Tau CSF (pg/ml) (Mean±SD) | – | 591.50±227.10 | 626.10±270.50 | 0.667d |
Normality assumption was evaluated by Shapiro-Wilk test. CTRL, controls; AD, Alzheimer’s disease patients; MCI-AD, Mild Cognitive Impairment converting to AD; MMSE, Mini-Mental State Examination. aChi-squared test, bKruskal-Wallis test, cMann-Whitney Test, dt-test. Median, 25% Percentile, 75% Percentile are reported for the non-normal distributed variables. SD, standard deviation. Disease onset for MCI-AD refers at first diagnosis, before conversion.