Table 1.
Studies that described non-demented individuals with AD neuropathology (NDAN), using different synonyms. These studies all focus on non-demented individuals with AD neuropathology or preclinical AD, studying brain tissue and/or data on cognitive performance. Cognitive assessment and AD pathology scores are specified in Tables 2 and 3, respectively
| Synonyms of NDAN | Cohort study/Data set | Reference |
| Non-demented individuals with Alzheimer’s Neuropathology (NDAN) | Oregon Brain Bank at Oregon Health and Science University | [9, 10, 223] |
| Nondemented high potential controls (ND-HPC) | Banner Sun Health Research Institute: Brain and Body Donation Program | [11] |
| Asymptomatic person with AD neuropathology | National Alzheimer’s Coordinating Center: Uniform Data Set and Neuropathology Data Set | [12] |
| Intermediate probability mismatches | Massachusetts General Hospital, Mayo Clinic and University of Pittsburgh ADRC Brain Banks | [13, 178] |
| ‘Asymptomatic AD’ (ASYMAD) | The Nun Study/Baltimore Longitudinal Study of Aging (BLSA)/ | [17–20, 179] |
| Cognitively normal with significant AD pathology | Medical Research Council London Neurodegenerative Diseases Brain Bank | |
| Amyloid-PET positive subjective memory complaint seniors (SMCpos) | INveStIGation of AlzHeimer’s PredicTors (INSIGHT) – preAD study | [61, 172, 173, 242] |
| Presymptomatic or incipient AD | Dementia of Alzheimer type | [63] |
| Preclinical AD | – | [64] |
| Pathologically preclinical AD | – | [79] |
| SuperAgers | Australian Imaging, Biomarkers and Lifestyle (AIBL) study of Aging / | [170, 176, 177] |
| 80+-year-olds, protected from Aβ neurodegeneration | Alzheimer’s Disease Neuroimaging Initiative (ADNI) | |
| Cognitive reserve | – | [174, 175] |