Table 2.
Rates of aGVHD and cGVHD and complications after stem cell transplantation
| Variable | CsA/MPA (n = 52), n (%) | PT-Cy/CsA (n = 99), n (%) | P value |
|---|---|---|---|
| Nonsevere GVHD <180 d posttransplant | 15 (29) | 38 (38) | .26 |
| aGVHD | 34 (65) | 64 (65) | 1.00 |
| Maximum overall grade per patient* | |||
| Grade 1 | 5 (10) | 31 (31) | |
| Grade 2 | 21 (40) | 27 (27) | |
| Grade 3 | 6 (12) | 5 (5) | |
| Grade 4 | 2 (4) | 1 (1) | |
| cGVHD | 36 (69) | 49 (49) | .025 |
| Maximum overall grade per patient† | |||
| Limited | 9 (17) | 25 (25) | |
| Extensive | 27 (52) | 24 (24) | |
| CTC grade 3-5 AEs <6 mo posttransplant ‡ | |||
| All events | 22 (42) | 60 (61) | .039 |
| Infections | 11 (21) | 41 (41) | .019 |
| Febrile neutropenia | 8 (15) | 25 (25) | .22 |
| Invasive pulmonary aspergillosis | 2 (4) | 4 (4) | 1.00 |
| Pulmonary infections other | — | 3 (3) | .55 |
| CMV disease | — | 1 (1) | 1.00 |
| Graft failure | 1 (2) | 1 (1) | 1.00 |
| Cardiac | 2 (4) | 3 (3) | 1.00 |
CMV, cytomegalovirus; CTC, common toxicity criteria.
*
Severity of aGVHD according to the updated Glucksberg classification (supplemental Table 1).
†
Severity of cGVHD according to the Seattle criteria (supplemental Table 2).
‡
The complete list of CTC grade 3 to 5 events <6 mo posttransplantation is available in supplemental Table 4.